Evidence map›Paper›PMID 40997102›Full record

ArticlePLoS biology2025

Microsaccades strongly modulate but do not directly cause the EEG N2pc marker of spatial attention.

Baiwei Liu, Siyang Kong, Freek van Ede

Abstract read
In one paragraph

Article in PLoS biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Baiwei LiuDepartment of Experimental and Applied Psychology, Institute for Brain and Behavior Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-7857-4456
Siyang KongDepartment of Experimental and Applied Psychology, Institute for Brain and Behavior Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Freek van EdeDepartment of Experimental and Applied Psychology, Institute for Brain and Behavior Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Funding

Dutch Research CouncilEuropean Research CouncilNWO Vidi
6 · The paper itself

Abstract

The N2pc is a popular human-neuroscience marker of covert and internal spatial attention that occurs 200-300 ms after being prompted to shift attention-a time window also characterized by the spatial biasing of small fixational eye movements known as microsaccades. Here, we show how co-occurring microsaccades profoundly modulate N2pc amplitude during top-down shifts of spatial attention in both perception and working memory. At the same time, we show that a significant-albeit severely weakened-N2pc can still be established in the absence of co-occurring microsaccades. Moreover, despite the strong modulation of the N2pc by microsaccade presence and direction, the N2pc does not align to the precise timing of microsaccades, ruling out that the observed N2pc modulations by microsaccades are a direct artifact of microsaccade-related eye-muscle activity, corneo-retinal dipole movement, or visual inputs moving over the retina. Thus, while microsaccades strongly modulate N2pc amplitude, microsaccades themselves are not a prerequisite for, nor a direct cause of, the N2pc.

Indexed as

AttentionSaccadesSpace PerceptionAdultElectroencephalographyFemaleHumansMaleMemory, Short-TermPhotic StimulationYoung Adult

Identifiers

PMID40997102
PMCPMC12500154

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.