ReviewDiscover oncology2025
Decoding the functional roles of circular RNAs linked to NF-κB pathway in carcinogenesis.
Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
6 authors.
Funding
Abstract
CircRNAs, a class of covalently closed noncoding RNAs, have emerged as pivotal regulators of the NF-κB signaling pathway in carcinogenesis. Accumulating evidence demonstrates that the circRNA/NF-κB axis regulates key cancer-related processes, such as proliferation, invasion, apoptosis, and immune escape. These regulatory effects are mediated by circRNAs' functional mechanisms-including miRNA sponging, direct protein interactions, and translation into functional peptides-which converge on modulating NF-κB pathway activity. Expression levels of NF-κB-associated circRNAs correlate with clinicopathological features such as tumor stage, metastasis, and patient survival. Furthermore, these circRNAs hold promise as diagnostic and prognostic biomarkers and as novel targets for therapeutic intervention. In this review, we summarize recent advances in elucidating the mechanisms and clinical relevance of NF-κB-linked circRNAs across diverse cancer types.
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Registered trials
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