Evidence map›Paper›PMID 40996656›Full record

ArticleStem cell reviews and reports2026

Circulating Endothelial Compartment and Progenitor Cell Dynamics in Idiopathic Pulmonary Fibrosis: Findings from the COFI Trial.

David M Smadja, Hilario Nunes, Karine Juvin, Raphael Borie, Laetitia Mauge, Bruno Crestani, Adeline Blandinières, Zohra Carton, Aurélien Philippe, Sébastien Bertil and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

David M SmadjaParis Cité University, INSERM PARCC, UMR-S 970, Paris, France. david.smadja@me.com.ORCID 0000-0001-7731-9202
Hilario NunesUniversité Sorbonne Paris Nord Bobigny, Bobigny, France.
Karine JuvinRespiratory Disease Department, AP-HP, Hôpital européen Georges Pompidou, Paris, France.
Raphael BorieService de pneumologie, AP-HP, Hôpital Bichat, Université Paris Cité, Inserm, U1149, Paris, 75018, France.
Laetitia MaugeParis Cité University, INSERM PARCC, UMR-S 970, Paris, France.
Bruno CrestaniService de pneumologie, AP-HP, Hôpital Bichat, Université Paris Cité, Inserm, U1149, Paris, 75018, France.
Adeline BlandinièresParis Cité University, INSERM PARCC, UMR-S 970, Paris, France.
Zohra CartonHôpital Avicenne, Respiratory disease and oncology Department, Centre Constitutif Maladies Pulmonaires Rares de l'adulte Pneumology and thoracic oncology Department, AP-HP, Bobigny, France.
Aurélien PhilippeParis Cité University, INSERM PARCC, UMR-S 970, Paris, France.
Sébastien BertilHematology Department, AP-HP, Hôpital européen Georges Pompidou, Paris, France.
Dominique ValeyreUniversité Sorbonne Paris Nord Bobigny, Bobigny, France.
Dominique Israel-BietParis Cité University, INSERM PARCC, UMR-S 970, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease in which the contribution of vascular alterations remains poorly understood. While most previous studies focused on epithelial and fibroblast dysfunction, recent evidence suggests that endothelial cell injury and vascular remodeling are integral to disease pathogenesis. This study aimed to longitudinally characterize the circulating endothelial compartment in IPF and explore its association with clinical outcomes. In this multicenter substudy of the COFI (COhorte FIbrose) prospective cohort, 95 patients with IPF underwent 243 serial assessments of circulating endothelial biomarkers. These included the quantification of circulating endothelial cells (CECs) using immunomagnetic isolation, and CD34⁺CD45

Indexed as

Endothelial CellsEndothelial Progenitor CellsIdiopathic Pulmonary FibrosisStem CellsAgedAntigens, CD34BiomarkersFemaleHumansMaleMiddle AgedProspective StudiesAntigens, CD34BiomarkersBiomarkersCirculating endothelial cellsEndothelial Colony-Forming cellsEndothelial progenitor cellsIdiopathic pulmonary fibrosis

Identifiers

PMID40996656

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.