Evidence map›Paper›PMID 40996654›Full record

ArticleBulletin of experimental biology and medicine2025

Protective Effect of Conditioned Medium from Bone Marrow Mesenchymal Stem Cells on the Cornea of Rabbits with Impaired Blink Reflex.

V V Tiulina, S V Lavrushkina, A I Dovgii, I I Senin

Abstract read
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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

V V TiulinaA. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
S V LavrushkinaA. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
A I DovgiiT-Helper Cell Technologies LLC, Moscow, Russia.
I I SeninA. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. senin@belozersky.msu.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the efficiency of a conditioned medium containing the secretome of bone marrow mesenchymal stem cells in preventing corneal damage in rabbits using an experimental model of dry eye syndrome caused by impaired blinking reflex. The conditioned medium produced a pronounced protective effect on the epithelial layer of the cornea of rabbits and suppressed the activation of MMP-9 in the tear film. As is known, an increase in MMP-9 activity leads to degradation of extracellular matrix components and disruption of the corneal epithelial barrier function. Our results indicate the possibility of using the bone marrow mesenchymal stem cell secretome in the treatment of dry eye syndrome.

Indexed as

BlinkingCorneaDry Eye SyndromesMesenchymal Stem CellsAnimalsBone Marrow CellsCulture Media, ConditionedDisease Models, AnimalMaleMatrix Metalloproteinase 9RabbitsTearsCulture Media, ConditionedMatrix Metalloproteinase 9CorneaDry eye syndromeMatrix metalloproteinase-9Stem cell secretomeTear film

Identifiers

PMID40996654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.