Evidence map›Paper›PMID 40996651›Full record

ArticleBulletin of experimental biology and medicine2025

Generation of a HEK293 Cell Line with Stable Expression of Molecular Tools for Thermogenetic Activation.

V S Ovechkina, P S Suvorova, S K Andrianova, V V Belousov, A A Mozhaev

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

V S OvechkinaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. vs_ovechkina@mail.ru.
P S SuvorovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
S K AndrianovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
V V BelousovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
A A MozhaevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In modern biotechnological and biomedical research, it is often necessary to activate mammalian cells to obtain a specific response, such as changes in membrane potential or generation of action potential in excitable cells and tissues. Thermogenetics provides a rapid and controlled cellular response and is a promising tool for such tasks. In order to explore the potential of thermogenetic approaches, we generated the HEK293 cell line stably expressing the thermosensitive human TRPV1 ion channel. This cell line exhibited an increase in intracellular Ca

Indexed as

TRPV Cation ChannelsCalciumCapsaicinHEK293 CellsHumansCalciumCapsaicinTRPV1 protein, humanTRPV Cation ChannelsCRISPR/Cas9genome editingHEK293thermogenetics

Identifiers

PMID40996651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.