Evidence map›Paper›PMID 40996598›Full record

ArticleAmerican journal of clinical dermatology2026

Performance of Staging Systems for Non-head and Neck Cutaneous Squamous Cell Carcinoma.

Lindsey M Voller, Kelsey E Hirotsu, Sumaira Z Aasi, Melica Nikahd, Emily Ruiz, Nina Ran, Emily E Granger, Shlomo Koyfman, Allison Vidimos, Ashley Wysong and 11 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in American journal of clinical dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lindsey M Voller *Department of Dermatology, Stanford Medicine, Redwood City, CA, USA.
Kelsey E Hirotsu *Department of Dermatology, Stanford Medicine, Redwood City, CA, USA.
Sumaira Z AasiDepartment of Dermatology, Stanford Medicine, Redwood City, CA, USA.
Melica NikahdCenter for Biostatistics, The Ohio State University Medical Center, Columbus, OH, USA.
Emily RuizDepartment of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.
Nina RanDepartment of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.
Emily E GrangerDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, MD, USA.
Shlomo KoyfmanDepartment of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA.
Allison VidimosDepartment of Dermatology, Cleveland Clinic, Cleveland, OH, USA.
Ashley WysongDepartment of Dermatology, University of Nebraska Medical Center, Omaha, NE, USA.
John A CarucciDepartment of Dermatology, New York University School of Medicine, New York, NY, USA.
Joi B CarterDepartment of Dermatology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Javier CañuetoDepartment of Dermatology, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain.
Fabio Muradás GirardiDepartment of Head and Neck Surgery, Ana Nery Hospital, Santa Cruz do Sul, RS, Brazil.
Aaron R MangoldDepartment of Dermatology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Divya SrivastavaDepartment of Dermatology, University of Texas Southwestern School of Medicine, Dallas, TX, USA.
David G BrodlandZitelli and Brodland P.C., Pittsburgh, PA, USA.
John A ZitelliZitelli and Brodland P.C., Pittsburgh, PA, USA.
Tyler J WillenbrinkZitelli and Brodland P.C., Pittsburgh, PA, USA.
Kathryn T ShahwanDepartment of Dermatology, The Ohio State University Medical Center, Columbus, OH, USA. Kathryn.Shahwan@osumc.edu.ORCID http://orcid.org/0000-0002-2259-1150
David R CarrDepartment of Dermatology, The Ohio State University Medical Center, Columbus, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundData are limited regarding the performance of staging systems for non-head and neck cutaneous squamous cell carcinomas (non-HNCSCCs).

objectiveThe aim of this study was to evaluate the performance of the Brigham and Women's Hospital (BWH) and American Joint Committee on Cancer 8th edition (AJCC8) staging system in predicting poor outcomes in non-HNCSCCs. PATIENTS AND

methodsDemographics, tumor features and stages, and outcomes for non-HNCSCCs were collected retrospectively from 11 institutions in two countries. Poor outcomes included local recurrence, metastasis, and disease-specific death; major poor outcomes excluded local recurrence. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), concordance index (c-index), and 3-year cumulative incidence were calculated. Cumulative incidence function (CIF) plots were created.

results9300 non-HNCSCCs were included. Ninety-five tumors (1%) resulted in major poor outcomes; 250 (2.7%) resulted in poor outcomes. The rate of local recurrence was 1.9%, and the rate of nodal metastasis was 0.74%. Major poor outcomes were predicted with sensitivities 0.48/0.49, specificities 0.98/0.96, PPVs 0.17/0.13, NPVs 0.99/0.99, and c-indices 0.73/0.74 for BWH/AJCC8. Poor outcomes were predicted with sensitivities 0.24/0.26, specificities 0.98/0.97, PPVs 0.22/0.17, NPVs 0.98/0.98, and c-indices 0.61/0.61 for BWH/AJCC8.

conclusionsBoth systems performed similarly in predicting poor outcomes in non-HNCSCCs. Specificity and NPV were high, sensitivity and PPV were low, and c-indices were moderately high. As the c-indices were comparable to those seen in the HNCSCC literature, it is reasonable to use the BWH and AJCC8 staging systems for tumors located off the head and neck. However, further refinement of CSCC staging systems is needed to improve prognostication.

Indexed as

Carcinoma, Squamous CellNeoplasm Recurrence, LocalNeoplasm StagingSkin NeoplasmsAdultAgedAged, 80 and overFemaleHumansIncidenceLymphatic MetastasisMaleMiddle AgedPredictive Value of TestsPrognosisRetrospective Studies

Identifiers

PMID40996598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.