Observational studyInternational orthopaedics2025
Value the importance of routine biopsy during vertebral augmentation: a prospective observational study of one hundred and forty one patients.
Observational study in International orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Accuracy of CT- vs. Fluoroscopic-Guided Biopsy in Spinal Lesions.Journal of clinical medicine · 2026Article
- Comment on "Prevalence, associated factors, and short-term impact of central sensitization in high-altitude patients undergoing total knee arthroplasty".International orthopaedics · 2025Article
- Letter to the editor on "Efficacy of focused low-intensity pulsed ultrasound in reducing lower-extremity swelling and pain after total knee arthroplasty: a randomized study".International orthopaedics · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundOsteoporotic vertebral compression fractures (OVCFs) are highly prevalent among the elderly. However, spinal metastases can also lead to pathological fractures that are often misdiagnosed as OVCFs. This study aimed to determine the prevalence of unsuspected malignant vertebral compression fractures (VCFs) among patients initially suspected to have OVCFs.
methodsFrom October 2020 to December 2023, 141 patients with suspected OVCFs underwent routine vertebral biopsy during percutaneous kyphoplasty (PKP) at our institution. All patients received standardized treatment and prospective clinical data collection. Follow-up questionnaires were completed in person or via telephone.
resultsA total of 168 biopsy specimens were obtained from 141 patients, and all samples (100%) were successfully evaluated histopathologically. Unexpected spinal metastases were identified in six patients (4.3%). Of the 19 patients with a known history of malignancy but without characteristic radiographic features of pathological fracture, only two cases (10.5%) were confirmed as metastatic involvement from the primary cancer. Among the remaining 112 patients without a cancer history, four unexpected malignancies were identified (one lymphoma and three lung cancers). The overall prevalence of unsuspected malignant VCFs in this cohort was 4.3%.
conclusionsGiven the observed prevalence of unsuspected malignant VCFs, we recommend that routine vertebral biopsy be performed during every PKP procedure for patients with OVCFs to ensure early detection of occult malignancy.
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