Evidence map›Paper›PMID 40996489›Full record

ReviewGenes & genomics2025

Emerging technologies and clinical translation of urine-based liquid biopsy in urological cancers.

Seo-Yeong Yoon, Gi-Eun Yang, Jong-Kil Nam, Hyeok-Jun Goh, Tae-Nam Kim, Sun-Hee Leem

Abstract readReview
PubMed Publisher
In one paragraph

Review in Genes & genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Seo-Yeong YoonDepartment of Biomedical Sciences, Dong-A University, Busan, 49315, Korea.
Gi-Eun YangDepartment of Biomedical Sciences, Dong-A University, Busan, 49315, Korea.
Jong-Kil NamDepartment of Urology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Yangsan, 50612, Korea.
Hyeok-Jun GohDepartment of Urology, College of Medicine, Dong-A University, Busan, 49201, Korea.
Tae-Nam KimDepartment of Urology, Pusan National University Hospital, Pusan National University School of Medicine, Biomedical Research Institute and Pusan National University Hospital, Busan, 49241, Korea. bigman1995@hanmail.net.
Sun-Hee LeemDepartment of Biomedical Sciences, Dong-A University, Busan, 49315, Korea. shleem@dau.ac.kr.ORCID http://orcid.org/0000-0001-6371-7971

Funding

Dong-A University Dong-A University
6 · The paper itself

Abstract

Urine-based liquid biopsy represents a transformative, non-invasive diagnostic approach that enables the molecular profiling of tumor-derived biomarkers shed into the urinary tract. By overcoming the limitations of traditional tissue biopsies, this methodology facilitates early cancer detection, real-time monitoring of therapeutic response, and longitudinal disease surveillance. This review provides a comprehensive overview of current urine-based liquid biopsy platforms, with a focus on protein and RNA biomarkers in urological cancers. We highlight the clinical relevance of these biomarkers and discuss technological innovations-including multi-omics integration, machine learning applications, and point-of-care testing-that are expanding their diagnostic utility. By leveraging the unique anatomical accessibility of urological malignancies via urine sampling, this field is poised to significantly enhance precision oncology.

Indexed as

Biomarkers, TumorUrologic NeoplasmsHumansLiquid BiopsyBiomarkers, TumorBiomarkersUrine-based liquid biopsyUrological cancer

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.