Evidence map›Paper›PMID 40996370›Full record

ArticleJournal of veterinary internal medicine

Single-Voxel Proton Magnetic Resonance Spectroscopy Findings at 3 Tesla in a Dog With Gliomatosis Cerebri.

Péter Sebestyén, Chris Staudinger, Robert Herzig, Anna Oevermann, Lorenzo Golini, Niklaus Zölch, Katrin Beckmann

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Péter SebestyénSection of Neurology, Department of Small Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0009-0005-9972-9719
Chris StaudingerClinic for Diagnostic Imaging, Department of Clinical Diagnostics and Services, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-5536-2733
Robert HerzigSection of Neurology, Department of Small Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-9216-8462
Anna OevermannDivision of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Lorenzo GoliniSection of Neurology, Department of Small Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Niklaus ZölchDepartment of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland.
Katrin BeckmannSection of Neurology, Department of Small Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-1823-7845

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gliomatosis cerebri (GC) represents an antemortem diagnostic challenge in the absence of histopathology. Proton magnetic resonance spectroscopy (1H-MRS) features of the disease in humans include elevated myo-inositol (mI)-to-creatine and decreased N-acetyl-aspartate (NAA)-to-creatine ratios. Brain 1H-MRS findings at 3 Tesla (3 T) field strength in dogs with GC have not yet been described. A 12-year-old West Highland White Terrier was presented with a progressive history of multifocal encephalopathy. A 3 T MRI revealed a diffuse, bilateral, ill-defined, intra-axial white matter lesion that was T2W and FLAIR hyperintense, T1W iso- to hypointense, showed no contrast enhancement, and was associated with moderate mass effect. 1H-MRS with voxel positioning at the left parietal area showed highly elevated mI and decreased NAA levels compared to healthy control dogs measured using the same protocol in the thalamus. GC was confirmed by stereotactic brain biopsy. Comparable 1H-MRS changes to those reported in humans were identified in a dog with GC.

Indexed as

Brain NeoplasmsDog DiseasesNeoplasms, NeuroepithelialProton Magnetic Resonance SpectroscopyAnimalsAspartic AcidBrainDogsFemaleInositolMagnetic Resonance ImagingMaleAspartic AcidInositolN-acetylaspartate1H‐MRSbilateral symmetric lesionsintracranial neoplasiamyo‐inositolNAAneuroimaging

Identifiers

PMID40996370
PMCPMC12462539

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.