ArticleMicrobiology spectrum2025
Effects of two kinds of marine algae polysaccharides and their oligosaccharides on lipid metabolism and gut microbiota in high-fat diet mice.
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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4 authors.
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Abstract
Abnormal lipid metabolism is manifested in a variety of metabolic diseases. In recent years, studies have shown that the pathogenesis of these disorders is closely associated with the gut microbiota. Marine algae polysaccharides, such as sodium alginate and its oligosaccharides, can reduce blood lipids and improve lipid metabolism to reduce body weight. Polysaccharides are difficult to be absorbed by the human body due to their large molecular weight, which limits their application in the field of medicine and food. In this study, two kinds of marine algae polysaccharides and their oligosaccharides were used to investigate their effects on body weight, lipid metabolism, inflammatory factors, and intestinal health and microbiota in high-fat diet mice. The results showed that after feeding a high-fat diet, the mice's body weight and serum lipids were increased. The formation of fat droplets was observed in the liver cells. Small intestinal microvilli were destroyed and showed obvious accumulation of epithelial cells. After feeding mice with sodium alginate, agar, and its oligosaccharides, the level of body weight and the pathological damage of the liver and intestine were relieved. Gut microbiota analysis showed that two kinds of polysaccharides and their oligosaccharides could improve the composition of gut microbiota at the phylum and genus level, increase the abundance of
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