Evidence map›Paper›PMID 40996285›Full record

ArticleJournal of microbiology & biology education2025

Preliminary assessment of drug repurposing against virus-associated primary effusion lymphoma.

Daniela Plaza, Gabriella Chefitz, Emily R McKiernan, Sophie E Sandler, Clara Levrero, Kang Kim, Emma R Germano, Sarah Braner, Lina A Ariyan, Jj L Miranda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology & biology education, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniela PlazaDepartment of Biology, Barnard College, Columbia University, New York, New York, USA.
Gabriella ChefitzDepartment of Biology, Barnard College, Columbia University, New York, New York, USA.
Emily R McKiernanDepartment of Biology, Barnard College, Columbia University, New York, New York, USA.
Sophie E SandlerDepartment of Biology, Barnard College, Columbia University, New York, New York, USA.
Clara LevreroDepartment of Biology, Barnard College, Columbia University, New York, New York, USA.
Kang KimDepartment of Biology, Barnard College, Columbia University, New York, New York, USA.
Emma R GermanoDepartment of Biology, Barnard College, Columbia University, New York, New York, USA.
Sarah BranerDepartment of Biology, Barnard College, Columbia University, New York, New York, USA.
Lina A AriyanDepartment of Biology, Barnard College, Columbia University, New York, New York, USA.
Jj L MirandaDepartment of Biology, Barnard College, Columbia University, New York, New York, USA.ORCID 0000-0002-5352-1438

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug repurposing uses medicine with a given indication to treat a different disease. Primary effusion lymphoma (PEL), a cancer driven by coinfection with the Kaposi sarcoma-associated herpesvirus and the Epstein-Barr virus, lacks an effective treatment. We optimized a rapid, informative, and educational protocol for quantitatively evaluating repurposed small molecules against PEL. The approach tests measurements of PEL cell growth and viability in culture against known inhibitory concentrations. We demonstrate proper quantitative interpretation of the data by using ethacrynic acid, quizartinib, and darapladib as examples. We hope that this practical experimental pipeline will spread awareness of the potential of drug repurposing, especially for diseases like PEL that have unmet clinical needs.

Indexed as

cell proliferationdrug repositioningherpesvirus 4, humanherpesvirus 8, humaninhibitory concentration 50primary effusion lymphoma

Identifiers

PMID40996285
PMCPMC12687644

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.