Evidence map›Paper›PMID 40996229›Full record

ArticlemBio2025

Type VII secretion system deploys an active iron uptake pathway to enhance bacterial fitness and counteract host nutritional immunity.

Chunhui Luo, Xinwei Hao, Xiao Wang, Mohua Liu, Shukun Chen, Conghui Wu, Chen Li, Can Chen, Mingming Yang, Lei Xu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The mycomembrane proteins PorH and ProtX are inserted at polar growth zones and linked to the cell wall.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chunhui Luo *Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.
Xinwei Hao *Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.
Xiao WangShaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.
Mohua LiuShaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.
Shukun ChenShaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.
Conghui WuShaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.
Chen LiShaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.
Can ChenKey Laboratory of Plant Genetics and Molecular Breeding, Henan Key Laboratory of Crop Molecular Breeding and Bioreactor, School of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, China.
Mingming YangCollege of Plant Protection, Northwest A&F University, Yangling, Shaanxi, China.
Lei XuShaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.ORCID 0000-0002-9886-3677
Yao WangShaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.ORCID 0000-0002-7149-4234
Xihui ShenShaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.ORCID 0000-0001-6867-8887

Funding

National Key Research and Development Program of China 2021YFA0909600National Natural Science Foundation of China 31725003National Natural Science Foundation of China 32170130National Natural Science Foundation of China 32270134National Natural Science Foundation of China 32330004National Natural Science Foundation of China 32570140Natural Science Foundation of Henan Province 252300420226Shaanxi Fundamental Science Research Project for Chemistry & Biology No. 22JHZ008
6 · The paper itself

Abstract

Type VII secretion systems (T7SS) are increasingly recognized as pivotal for bacterial adaptation across both environmental and host-associated niches in Gram-positive bacteria. Although T7SS has been reported to contribute to iron acquisition, the possibility of an active, more targeted iron uptake mechanism remains underexplored. Here, we reveal a distinct, active T7SS-mediated iron import mechanism in

Indexed as

Corynebacterium glutamicumIronType VII Secretion SystemsBacterial ProteinsGene Expression Regulation, BacterialLeukocyte L1 Antigen ComplexMycobacterium smegmatisOxidative StressRepressor ProteinsBacterial Proteinsferric uptake regulating proteins, bacterialIronLeukocyte L1 Antigen ComplexRepressor ProteinsType VII Secretion Systemshost–pathogen interactionsiron acquisitionnutritional immunityoxidative stresstype VII secretion system (T7SS)

Identifiers

PMID40996229
PMCPMC12607788

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.