Evidence map›Paper›PMID 40996098›Full record

ArticleJournal of the American Heart Association2025

Methadone Blockade of Inward Rectifier Potassium Current Promotes Both Early and Delayed Repolarization Arrhythmias: Mechanistic Insights From Computational Modeling.

Zhaoyang Zhang, J T Green, Mark C Haigney, Patrick Walker, Kalyanam Shivkumar, Alan Garfinkel, Zhilin Qu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhaoyang ZhangDepartment of Physics, School of Physical Science and Technology Ningbo University Ningbo Zhejiang China.ORCID 0000-0002-0656-366X
J T GreenMilitary Cardiovascular Outcomes Research Program, Department of Medicine Uniformed Services University of the Health Sciences Bethesda MD USA.
Mark C HaigneyMilitary Cardiovascular Outcomes Research Program, Department of Medicine Uniformed Services University of the Health Sciences Bethesda MD USA.ORCID 0000-0001-6449-4386
Patrick WalkerBattlefield Shock and Organ Support Lab Uniformed Services University of the Health Sciences Bethesda MD USA.ORCID 0000-0002-0871-2702
Kalyanam ShivkumarUCLA Center for Interventional Programs and Department of Medicine (Cardiology) David Geffen School of Medicine, University of California Los Angeles CA USA.ORCID 0000-0002-4121-1766
Alan GarfinkelUCLA Center for Interventional Programs and Department of Medicine (Cardiology) David Geffen School of Medicine, University of California Los Angeles CA USA.
Zhilin QuUCLA Center for Interventional Programs and Department of Medicine (Cardiology) David Geffen School of Medicine, University of California Los Angeles CA USA.ORCID 0000-0001-5217-6022

Funding

Neural Control of Myocardial Excitability at the Nerve Myocyte InterfaceP01HL164311 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KALYANAM SHIVKUMAR · 2023 to 2026
$11.3M
SK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular ArrhythmogenesisR01HL139829 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI PENG-SHENG CHEN, ZHILIN QU · 2018 to 2026
$4.5M
Ferroptosis in the Heart: Iron Calcium Crosstalk and CompartmentalizationR01HL157116 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI GWATHMEY, JUDITH K, XIE, LAI-HUA · 2022 to 2025
$2.4M
A population-based computational approach for arrhythmia prediction and therapyR01HL175074 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHILIN QU · 2024 to 2026
$1.2M
NHLBI NIH HHS P01 HL164311NHLBI NIH HHS R01 HL139829NHLBI NIH HHS R01 HL157116NHLBI NIH HHS R01 HL175074
6 · The paper itself

Abstract

backgroundMethadone blocks several ionic currents with different half-maximal inhibitory concentrations, including the rapid component of the delayed and inward (I

methodsComputer simulations were used to explore the proarrhythmic effects of methadone by investigating how its blocking effects on ionic currents act alone or together in arrhythmogenesis.

resultsThe major findings are (1) blocking I

conclusionsMethadone promotes both early and delayed repolarization arrhythmias. Early repolarization may be responsible for methadone-related deaths occurring mainly during sleep and occurring more often in men. Blocking I

Indexed as

Arrhythmias, CardiacComputer SimulationMethadoneModels, CardiovascularPotassium Channel BlockersPotassium Channels, Inwardly RectifyingAction PotentialsHumansMethadonePotassium Channel BlockersPotassium Channels, Inwardly RectifyingBrugada syndromeearly replarizationlong QT syndromemethadonephase 2 reentrytissue‐scale phenomenon

Identifiers

PMID40996098
PMCPMC12684491

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.