ArticleJournal of the American Heart Association2025
Effect of Phenylephrine on Cerebrovascular Regulation: A Translational Perspective.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Effect of Induced Hypertension Therapy According to the Mechanism of Single Subcortical Infarction.Journal of clinical neurology (Seoul, Korea) · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundPhenylephrine is an alpha 1-adrenergic receptor (α1R) agonist. Evidence indicates activation of α1Rs can initiate both vasoconstrictor and dilator signaling. How phenylephrine affects cerebrovascular regulation remains unclear.
methodsA retrospective analysis of data examining cerebral perfusion and blood pressure during systemic phenylephrine infusion in humans and swine was completed. Follow-up experiments examining cerebral hemodynamics during intracarotid arterial infusion of phenylephrine in anesthetized swine were performed. Ex vivo experiments were conducted on isolated porcine cerebral arteries.
resultsSystemic phenylephrine infusion increased indices of cerebrovascular resistance in both humans (
conclusionsNeither systemic nor intracarotid phenylephrine infusion compromised cerebral perfusion, possibly related to increased endothelial NO signaling and reduced α1R density in downstream pial arteries.
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