Evidence map›Paper›PMID 40996038›Full record

Observational studyJournal of the American Heart Association2025

Afterload Mismatch Is Associated With Higher Cardiac Mortality After Heart Transplantation.

Mattia Corianò, Nicola Pradegan, Andrea Golfetto, Vincenzo Tarzia, Annalisa Angelini, Chiara Tessari, Marny Fedrigo, Giuseppe Toscano, Gino Gerosa, Francesco Tona

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Beyond Rejection: Long-Term Survival Following Heart Transplant.Journal of the American Heart Association · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Mattia CorianòCardiology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Italy.ORCID 0000-0002-4583-280X
Nicola PradeganCardiac Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Italy.
Andrea GolfettoCardiology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Italy.
Vincenzo TarziaCardiac Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Italy.ORCID 0000-0003-2360-2031
Annalisa AngeliniPathology and Pathological Anatomy Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padova Italy.ORCID 0000-0002-3578-4488
Chiara TessariCardiac Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Italy.ORCID 0000-0001-9011-1625
Marny FedrigoPathology and Pathological Anatomy Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padova Italy.
Giuseppe ToscanoCardiac Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Italy.ORCID 0000-0002-3734-315X
Gino GerosaCardiac Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Italy.ORCID 0000-0002-6261-699X
Francesco TonaCardiology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Italy.ORCID 0000-0003-4828-7875

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHeart transplant (HT) recipients tend to develop unfavorable ventricular-arterial interactions, yet the prognostic implications of this altered physiology remain unclear. We aimed to identify the presence of afterload mismatch (AM) after heart transplantation, its determinants, and its impact on long-term cardiac mortality.

methodsAn observational, single-center study was conducted on the historical cohort of patients who received HT at our institution. Patients survived the first year after HT with a LVEF ≥50%, cardiac allograft vasculopathy grades 0 to 1, and acute cellular rejection grades 0 to 1R. Arterial elastance and ventricular elastance were calculated noninvasively using blood pressure, end-systolic volume, and end-diastolic volume. Patients were grouped as follows: low afterload (LA- arterial elastance <median), matched high afterload (MHA- arterial elastance ≥median, ventricular elastance ≥median), and AM (arterial elastance ≥median, ventricular elastance <median).

resultsOverall, 345 patients who received HT were enrolled. Left ventricular ejection fraction was lower in AM (57%) than in LA and MHA (63% and 64%, respectively;

conclusionThree phenotypes of patients who received HT were identified, and AM resulted as an independent predictor of cardiac mortality.

Indexed as

Heart TransplantationVentricular Function, LeftAdultFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsStroke VolumeTime FactorsVascular Stiffnessafterloadafterload mismatchheart transplantationphysiologypredicted heart masssex mismatchventricular‐arterial coupling

Identifiers

PMID40996038
PMCPMC12684555

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.