ArticleVeterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association2025
Case Report: MRI Diagnosis of Wilson's Disease in a 3-Year-Old Dalmatian.
Article in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Case Report: MRI Diagnosis of Wilson's Disease in a 3-Year-Old Dalmatian.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2025Article
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3 authors.
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Abstract
A 3-year-old Dalmatian was presented with anorexia, vomiting, and lethargy that progressed to neurological signs with a mixed hepatopathy. MRI identified bilaterally symmetric, ill-defined hyperintensities in the thalamus, medial and lateral geniculate bodies, and red nuclei on T2-weighted (T2W) and transverse T2W fluid-attenuation inversion-recovery (T2-FLAIR) images, and bilaterally symmetric, ill-defined T1-hyperintensities in the lentiform nuclei and thalamus suggestive of an underlying metabolic dysfunction. Systemic workup revealed an underlying hepatopathy. A hepatic biopsy revealed severe copper-associated hepatitis with a digital copper quantification of 3052 µg/g dry weight. Clinical signs and MRI changes both improved following chelation therapy. The MRI findings and hepatic biopsy results led to a diagnosis of copper storage hepatopathy, consistent with Wilson's disease. This is the first description of brain MRI findings secondary to Wilson's disease in dogs.
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