ArticleAdvanced healthcare materials2026
Ascorbic Acid Modulates Collagen Properties in Glucocorticoid-Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Osteoporosis is a prevalent skeletal disorder characterized by decreased bone mass and structural deterioration, leading to an increased risk of fractures. This study focuses on the regulatory role of Vitamin C (ascorbic acid; AA) in the context of glucocorticoid-induced osteoporosis (GIOP), which results from long-term glucocorticoid (GC) therapy. The data showed that GCs impair AA metabolism in osteoblasts, thereby disrupting collagen synthesis and compromising extracellular matrix (ECM) integrity. Notably, AA integration in the collagen matrix improved its biochemical and mechanical properties. Additionally, it has been shown that the presence of AA restored osteoblast and endothelial function, enhanced collagen production, and improved endothelial barrier function under GC exposure. These results underscore the critical role of Vitamin C in bone matrix maintenance and homeostasis. Collectively, this work highlights the therapeutic potential of Vitamin C as a supportive treatment to counteract the deleterious skeletal effects of long-term GC therapy.
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