Evidence map›Paper›PMID 40995696›Full record

ArticleBiology open2025

Coincident evolution and functional adaptation of the taxonomically restricted genes ivph-3 and gon-14 in Caenorhabditis nematodes.

Nikita Jhaveri, Bhagwati Gupta, Helen M Chamberlin

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In one paragraph

Article in Biology open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nikita JhaveriDepartment of Biology, McMaster University, Hamilton, ON L8S 4L8, Canada.ORCID 0009-0008-6434-2188
Bhagwati GuptaDepartment of Biology, McMaster University, Hamilton, ON L8S 4L8, Canada.ORCID 0000-0001-8572-7054
Helen M ChamberlinDepartment of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-7203-2691

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Genetic and genomic tools for C. briggsae researchR21OD030067 · OD · OHIO STATE UNIVERSITY · PI ANDERSEN, ERIK CHRISTIAN, CHAMBERLIN, HELEN M · 2022 to 2023
$431k
McMaster UniversityNational Institutes of Health (US) R21OD030067Natural Sciences and Engineering Research Council of CanadaNCI NIH HHS P30 CA016058NIH HHS P40 OD010440NIH HHS R21 OD030067NIH HHS R21OD030067Ohio State University
6 · The paper itself

Abstract

Poorly conserved or taxonomically restricted genes represent a sizable portion of most genomes. Many of these genes participate in essential processes and can contribute to evolutionary innovation in species. Here, we evaluate two of the Caenorhabditis-restricted class of LIN-15B-domain-encoding genes, ivph-3 and gon-14, and compare their in vivo functions in two species, C. elegans and C. briggsae. We show that within the Elegans supergroup, ivph-3 and gon-14 exhibit sequence constraints distinct from other family members, including maintenance of a one-to-one orthology and a higher degree of sequence conservation. Coincidentally, mutants for either of the genes exhibit strong phenotypic defects that are similar within species (C. elegans or C. briggsae), but with notable differences when comparing between species. These findings highlight the genetic and genomic features associated with the evolution of a taxonomically restricted gene family.

Indexed as

Adaptation, PhysiologicalCaenorhabditisEvolution, MolecularHelminth ProteinsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCarrier ProteinsModels, MolecularMutationPhylogenyProtein Structure, TertiaryRNA, HelminthTranscription, GeneticCaenorhabditis elegans ProteinsCarrier ProteinsGON-14 protein, C elegansHelminth ProteinsRNA, HelminthCaenorhabditis nematodesGene adaptationTaxonomically restricted genes

Identifiers

PMID40995696
PMCPMC12570147

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.