ReviewPeriodontology 20002025
Serum cytokines in periodontal diseases.
Review in Periodontology 2000, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association Between Ankylosing Spondylitis and Periodontitis: A Systematic Review.Oral health & preventive dentistry · 2026Pooled it
- Casearia sylvestris Derivatives Inhibit Inflammation and Oxidative Activity and Promote Healing in Human Gingival Fibroblasts - An In Vitro Study.Oral health & preventive dentistry · 2026Article
- Total Water Intake and Periodontitis in Korean Adults: Evidence from a Nationally Representative Survey.Oral health & preventive dentistry · 2026Article
- Assessment of Cardiologists' Knowledge, Attitudes, and Practices on Calcium Channel Blocker-Induced Gingival Overgrowth.Oral health & preventive dentistry · 2026Article
- Sex Differences in the Association Between Body Composition, Sarcopenic Obesity, and Periodontitis: Mediating Role of Oxidative Stress Markers.Oral health & preventive dentistry · 2026Article
- Combined Effect of Nitrate Levels and Diabetes on the Risk of Severe Periodontitis: A Cross-sectional Study.Oral health & preventive dentistry · 2026Article
- Treatment of Severe Periodontitis using Exosome-Mediated Combination Therapies: A Retrospective Cohort Study.Oral health & preventive dentistry · 2026Article
- Neutrophil-Derived Oncostatin M Contributes to Endothelial Cell Dysfunction DuringbioRxiv : the preprint server for biology · 2026Article
- Screening for Periodontitis Using Blood Biomarkers and Demographic Data: A Machine Learning Study.Oral health & preventive dentistry · 2026Article
- Periodontitis and Chronic Liver Disease: Mechanistic Insights Focusing onMicroorganisms · 2026Review
- Causal Association Between Transferrin Saturation and Periodontitis: A Mendelian Randomization Study.Oral health & preventive dentistry · 2026Article
- Similar Individual Serum Levels of MCP-1, TNF-α, and IL-6 From Periodontitis Patients Before and 1 Year After Treatment.Scandinavian journal of immunology · 2026Article
- Mediation of Systemic Inflammation and Oxidative Stress Markers in the Association of Life's Crucial 9 with Periodontitis: Evidence from NHANES 2009-2014.Oral health & preventive dentistry · 2026Article
- Review
- Neutrophil-derived oncostatin m contributes to endothelial cell dysfunction during Treponema denticola interaction.PloS one · 2026Article
- Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment.Frontiers in dental medicine · 2026Review
- Causal association and molecular mechanisms of periodontal disease and muscle wasting and atrophy: Mendelian randomization and bioinformatics analysis.Frontiers in genetics · 2026Article
- Salivary Biomarker Profiles in Pediatric Oral Candidiasis.Biomedicines · 2025Article
- Serum cytokines in periodontal diseases.Periodontology 2000 · 2025Review
- The relationship between maternal periodontitis and congenital cytomegalovirus: A hypothetical model and therapeutic implications.Periodontology 2000 · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Periodontal disease, including gingivitis and periodontitis, is a chronic inflammatory condition that leads to the destruction of the supporting structures of teeth. The disease is characterized by a complex immune response, where cytokines play a central role in regulating both inflammation and tissue breakdown. Cytokines are small signaling proteins that mediate communication between immune cells, driving the progression of periodontal diseases by activating immune cells, promoting osteoclast differentiation, and stimulating the production of matrix metalloproteinases. This leads to the degradation of periodontal ligament fibers, alveolar bone resorption, and eventual tooth loss. Cytokines contribute not only to localized tissue damage but also to systemic inflammation. Given that periodontal diseases are a chronic inflammatory diseases, their systemic implications are significant. Increasing evidence shows an association between periodontal diseases and other systemic conditions, suggesting that serum cytokine levels could provide valuable insights into both periodontal and systemic health. Understanding the role of serum cytokines in periodontal diseases is critical for identifying systemic inflammatory patterns and disease progression. Evaluating serum cytokine profiles may lead to the discovery of new diagnostic biomarkers and therapeutic targets. Cytokine-modulating therapies could potentially reduce the inflammatory burden in periodontal diseases and improve patient outcomes, especially in individuals with comorbid systemic conditions. This review highlights the current evidence on serum cytokines in periodontal diseases and emphasizes the need for further research to develop cytokine-targeted therapies for improved management of periodontal diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.