Evidence map›Paper›PMID 40995647›Full record

SynthesisPsychological medicine2025

Genetic overlap and causality between depression and preterm birth: a large-scale genome-wide cross-trait analysis.

Min Zhang, Xinzhen Chen, Wenzheng Zhou, Niya Zhou, Cuihua Zhang, Yunping Yang, Qiyin Li, Xin Ming, Yifu Wu, Hongbo Qi and 1 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Min ZhangDepartment of Sleep and Psychology, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing, China.
Xinzhen ChenClinical and Public Health Research Center, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing, China.
Wenzheng ZhouClinical and Public Health Research Center, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing, China.
Niya ZhouClinical and Public Health Research Center, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing, China.
Cuihua ZhangDepartment of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing, China.
Yunping YangDepartment of Quality Control, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing, China.
Qiyin LiDepartment of Sleep and Psychology, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing, China.
Xin MingDepartment of Quality Control, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing, China.
Yifu WuDepartment of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing, China.
Hongbo QiClinical and Public Health Research Center, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing, China.
Wei ZhouDepartment of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing, China.ORCID 0000-0001-7795-3166

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLittle is known regarding the shared genetic architecture underlying the phenotypic associations between depression and preterm birth (PTB). We aim to investigate the genetic overlap and causality of depression with PTB.

methodsLeveraging summary statistics from the largest genome-wide association studies for broad depression (N

resultsPositive genetic correlations were observed between PTB and broad depression (

conclusionsOur findings demonstrate an intrinsic link underlying depression and PTB and shed novel light on the biological mechanisms, highlighting an important role of early screening and effective intervention of depression in PTB prevention, and may provide novel treatment strategies for both diseases.

Indexed as

Bipolar DisorderMajor Depressive DisorderPremature BirthCausalityFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPregnancybipolar disorderdepressiongenome-wide cross-trait analysismajor depressionpreterm birthshared genetic architecture

Identifiers

PMID40995647
PMCPMC12527502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.