Evidence map›Paper›PMID 40995640›Full record

ArticleNucleic acids research2026

OncoDB 2.0: a comprehensive platform for integrated pan-cancer omics analysis.

Minsu Cho, Gongyu Tang, Charles S Rogers, Makayla Dove, Xinyi Liu, Yuanxiang Li, Xiaowei Wang

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Minsu ChoDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, United States.
Gongyu TangDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, United States.
Charles S RogersDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, United States.
Makayla DoveDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, United States.
Xinyi LiuDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, United States.
Yuanxiang LiDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, United States.
Xiaowei WangDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, United States.ORCID 0000-0001-9447-4685

Funding

MICRORNA BIOMARKERS FOR OROPHARYNGEAL CANCERR01DE026471 · NIDCR · WASHINGTON UNIVERSITY · PI WANG, XIAOWEI · 2017 to 2021
$2.2M
Combined Computational and Experimental Analyses of Gene Regulation by MicroRNAsR35GM141535 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WANG, XIAOWEI · 2021 to 2025
$2.1M
Combined Imaging and RNA Analyses to Develop Cervical Cancer BiomarkersR01CA287778 · NCI · WASHINGTON UNIVERSITY · PI Hua Li, Xiaowei Wang · 2024 to 2026
$2.0M
Combined Imaging and RNA Analyses to Predict Head and Neck Cancer RecurrenceR56DE033344 · NIDCR · WASHINGTON UNIVERSITY · PI LI, HUA, WANG, XIAOWEI · 2023 to 2023
$673k
NCI NIH HHS R01 CA287778NIDCR NIH HHS R01 DE026471NIDCR NIH HHS R56 DE033344NIGMS NIH HHS R35 GM141535NIH HHS R01CA287778NIH HHS R01DE026471NIH HHS R35GM141535
6 · The paper itself

Abstract

OncoDB was initially developed to advance cancer research by integrating RNA expression profiles, DNA methylation patterns, clinical annotations, and oncoviral signatures derived from the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression datasets. We now present OncoDB 2.0, an extensively expanded platform that offers a more comprehensive and integrated view of cancer omics. The updated version includes an atlas of somatic mutations discovered from combined DNA and RNA sequencing, enabling in-depth investigation of mutation patterns across tumor types and their association with clinical features. Furthermore, we have integrated proteomic data from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and chromatin accessibility data from TCGA, offering new dimensions for oncogene regulation studies. OncoDB 2.0 also introduces advanced multi-omics analysis modules that facilitate the combined exploration of RNA expression, DNA methylation, and somatic mutations, allowing researchers to examine complex cross-omic relationships with greater depth and flexibility. Together, these enhancements make OncoDB 2.0 a robust and invaluable tool for the cancer research community. OncoDB 2.0 is freely available at https://oncodb.org.

Indexed as

GenomicsNeoplasmsSoftwareDatabases, GeneticDNA MethylationGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMutationProteomics

Identifiers

PMID40995640
PMCPMC12808538

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.