ArticleJGH open : an open access journal of gastroenterology and hepatology2025
Potential Application Value of FASN in the Diagnosis of Colorectal Cancer.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Potential Application Value of FASN in the Diagnosis of Colorectal Cancer.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
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Authors and funding
6 authors.
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Abstract
Background: Fatty acid synthase (FASN) is a crucial enzyme that catalyzes endogenous lipogenesis in multiple diseases. However, the function and significance of FASN in colorectal cancer remain unclear. Aims: This research aimed to explore the expression and role of FASN in colorectal cancer. Results: Cancer, adjacent, and normal tissues were collected from patients with colorectal cancer and healthy controls. Immunohistochemistry and scoring were applied to analyze the expression of FASN in the different tissues, to investigate the differences in its expression among different tissue types, and to examine the potential correlation between FASN and gender, age, BMI, and other factors. Discussion: In this study, 100 colorectal cancer patients and 100 healthy participants were recruited. Respectively, the average scores of cancer tissues, adjacent tissues, and normal tissues were 7.25, 2, and 1.25. Significant differences were found among these three tissue groups ( Conclusion: Based on these data, FASN was specifically overexpressed in cancer tissues and adjacent tissues. Hence, our results suggest that FASN may play an essential role in colorectal cancer and may be an attractive therapeutic target in the future.
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