Evidence map›Paper›PMID 40995485›Full record

ArticleEnvironment & health (Washington, D.C.)2025

Cohort Evidence Links Phthalate Exposure to Early Onset of Puberty in Chinese Girls.

Yao Yao, Yuchen Li, Meiting Wei, Yu Wu, Yingying Li, Xiaoyi Liu, Congfu Huang, Weiqiang Liu, Fengxiang Wei, Li Zhou and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yao YaoAffiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen 518172, China.
Yuchen LiSchool of Data Science, The Chinese University of Hong Kong, Shenzhen 518172, China.
Meiting WeiDepartment of Preventive Medicine, Shantou University Medical College, Shantou 515041, China.
Yu WuShenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.
Yingying LiShenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.
Xiaoyi LiuAffiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen 518172, China.
Congfu HuangAffiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen 518172, China.
Weiqiang LiuAffiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen 518172, China.
Fengxiang WeiAffiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen 518172, China.
Li ZhouShenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.
Ying WenShenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.
Dingyan ChenShenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.ORCID https://orcid.org/0009-0003-5052-702X
Eddy Y ZengKey Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters (Ministry of Education), School of Environment and Energy, South China University of Technology, Guangzhou 510006, China.ORCID https://orcid.org/0000-0002-0859-7572

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Girls' age of onset puberty has decreased globally in recent years. Emerging evidence suggests that exposure to phthalate esters (PAEs) could play a role in this trend. However, the relationship between PAE exposure and pubertal development in Chinese girls remains poorly understood. The present study aimed to address this issue by investigating the link between levels of urinary phthalate ester metabolites (mPAEs) and the risk of early puberty among 546 Chinese girls (6-8 years old) over a two-year monitoring program. Poisson regression, restricted cubic spline models, weighted quantile sum regression, and Bayesian kernel machine regression were used to assess both individual and combined effects of PAEs on pubertal development. Significant links were found between urinary concentrations of monoisobutyl phthalate (MiBP), monobutyl phthalate (MnBP), mono-(2-ethyl-5-oxohexyl) phthalate, the total of low molecular weight mPAEs, the total of nine commonly detected mPAEs, and the total of all mPAEs with the risk of early breast development (all

Indexed as

Breast developmentExposureHealth riskOnset of menarchePhthalate metabolite

Identifiers

PMID40995485
PMCPMC12455343

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.