ArticleJHEP reports : innovation in hepatology2025
Genetic risk score correlates with immune profile and risk of HCC and cirrhosis development in Hispanics with MASLD.
Article in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Global trends in metabolic-associated hepatocellular carcinoma: genetic and socio-demographic drivers.Hepatology international · 2026Article
- Risk Assessment and Prediction of Hepatocellular Carcinoma in Noncirrhotic Metabolic Dysfunction-Associated Steatotic Liver Disease.International journal of molecular sciences · 2026Review
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Authors and funding
13 authors.
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Abstract
Background & Aims: Genetic risk score and immune dysregulations have been separately associated with the development of hepatocellular carcinoma (HCC) and cirrhosis in the context of metabolic dysfunction-associated steatotic liver disease (MASLD). Latin America has the highest prevalence of MASLD worldwide. However, the relationship between genetic risk scores, immune dysregulation, and MASLD has not been explored. Methods: We assessed SNPs of Results: At an individual level, only Conclusions: In Latin America, genetic risk score 6-8 in patients is strongly associated with an increased risk of MASLD-related HCC and cirrhosis. Additionally, patients with HCC and cirrhosis showed distinct immune profiles across high and low genetic risk score groups. Impact and implications: The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD)-related hepatocellular carcinoma (HCC) and cirrhosis is rising, with Hispanics having the highest MASLD rates. However, large-scale studies examining the association between genetic risk score, immune profiles, and the progression of MASLD-related HCC and cirrhosis are still lacking. In our study, we found that patients with MASLD-related HCC and cirrhosis who had higher genetic risk score were more likely to show higher odds ratios compared with those with lower genetic risk score. Additionally, genetic risk scores were found to be associated with immune profiles, as reflected by cytokine levels. These findings could assist clinicians in identifying high-risk groups of patients with MASLD-related HCC and cirrhosis and provide valuable insights into the potential immune changes in these individuals.
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