Evidence map›Paper›PMID 40995431›Full record

ArticleFrontiers in genetics2025

ZC3H18 regulates alternative splicing and related genes in cervical cancer.

Wenjuan Chen, Chenying Liu, Siyi Li, Xingyun Xie, Dan Hu, Yaobin Lin

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Wenjuan Chen *Department of Radiotherapy, Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Chenying Liu *Department of Radiotherapy, Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Siyi LiDepartment of Radiotherapy, Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Xingyun XieDepartment of Radiotherapy, Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Dan HuDepartment of Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Yaobin LinDepartment of Radiation Oncology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors (Fujian Medical University), Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Alternative splicing (AS) and RNA-binding proteins (RBPs) have been implicated in various diseases. However, a comprehensive understanding of their role in RNA metabolism, progression, and metastasis in cervical cancer remains elusive. This study aimed to identify the potential effect of zinc finger CCCH-type containing 18 (ZC3H18) in cervical cancer. Methods: The Gene Expression Omnibus (GEO) dataset (GSE94427) was used to analyze the expression level of ZC3H18 in HeLa cells and its regulated alternative splicing events (ASEs). The Cancer Genome Atlas (TCGA) cervical cancer dataset and in vitro experiments were used for verification. The signaling pathways and functions of ZC3H18-regulated ASEs were investigated through enrichment analysis. Results: Knockdown of ZC3H18 in HeLa cells increased the expression of 106 genes but decreased the expression of 226 genes. ZC3H18 was found to be involved in the regulation of 1,830 ASEs. The AS genes were enriched in cervical cancer-related signaling pathways. Validation using 39 cervical cancer samples from the TCGA database showed that 20 cases had low ZC3H18 expression and 19 had high expression. By integrating GEO and TCGA datasets along with in vitro experiments, 18 ASEs with consistent changes were identified. Discussion: This study demonstrated that ZC3H18 extensively regulates AS of cancer-associated pathways in HeLa cells and cervical cancer tissues. The identification of ZC3H18-regulated ASEs may provide potential targets for cervical cancer treatment.

Indexed as

alternative splicing eventscervical cancergenesRNA-binding proteinsZC3H18

Identifiers

PMID40995431
PMCPMC12454084

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.