Evidence map›Paper›PMID 40995398›Full record

ArticleClinical case reports2025

Coexistence of Renal Cell Carcinoma and Psoriasis in Tuberous Sclerosis Complex: A Shared mTOR Pathway Pathogenesis?

Sunil Jaiswal, Shraddha Uprety, Mukesh Kumar Ranjan, Pratichya Thapa, Bigyan Paudel, Prakriti Lamichhane

Abstract read
In one paragraph

Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sunil JaiswalDepartment of Dermatology Chitwan Medical College Bharatpur Nepal.ORCID https://orcid.org/0000-0003-3905-5247
Shraddha UpretyDepartment of Dermatology Chitwan Medical College Bharatpur Nepal.
Mukesh Kumar RanjanDepartment of Gastroenterology Chitwan Medical College Bharatpur Nepal.
Pratichya ThapaDepartment of Dermatology Chitwan Medical College Bharatpur Nepal.
Bigyan PaudelDepartment of Radiology Chitwan Medical College Bharatpur Nepal.
Prakriti LamichhaneDepartment of Dermatology Chitwan Medical College Bharatpur Nepal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberous sclerosis complex (TSC) is a rare multisystem genetic disorder characterized by benign hamartomas in multiple organs. Although renal manifestations such as angiomyolipomas and cysts are common, the occurrence of renal cell carcinoma (RCC) in tuberous sclerosis is rare. Similarly, psoriasis, which is an immune-mediated inflammatory skin disease, is not commonly associated with tuberous sclerosis. We hereby present a 30 year old male patient, a known case of TSC, who presented with extensive plaque psoriasis and was diagnosed with RCC during evaluation. The coexistence of RCC and psoriasis in a patient with tuberous sclerosis might be due to shared mTOR signaling pathway activation, which our study emphasizes.

Indexed as

mTOR pathwaypsoriasisrenal cell carcinomatuberous sclerosis complex

Identifiers

PMID40995398
PMCPMC12453948

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.