Evidence map›Paper›PMID 40995393›Full record

ArticleClinical case reports2025

Regenerative Endodontic Procedure of a Mature Anterior Tooth With Open Apex and Chronic Apical Abscess: A Case Report With 4-Years Follow-Up.

Murilo Priori Alcalde, Raimundo Sales de Oliveira Neto, Estela Franzolin Pires de Almeida, Renan Diego Furlan, Paulo Roberto Jara de Souza, Rodrigo Ricci Vivan, Pablo Andres Amoroso-Silva, Marco Antônio Húngaro Duarte, Guilherme Ferreira da Silva

Abstract read
In one paragraph

Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Murilo Priori AlcaldeDepartment of Dentistry, Endodontics and Dental Materials, Bauru Dental School University of São Paulo Bauru Brazil.
Raimundo Sales de Oliveira NetoDepartment of Dentistry, Endodontics and Dental Materials, Bauru Dental School University of São Paulo Bauru Brazil.ORCID https://orcid.org/0000-0002-4726-8106
Estela Franzolin Pires de AlmeidaDepartment of Dentistry Unisagrado Bauru Brazil.
Renan Diego FurlanDepartment of Dentistry Unisagrado Bauru Brazil.
Paulo Roberto Jara de SouzaDepartment of Dentistry Unisagrado Bauru Brazil.
Rodrigo Ricci VivanDepartment of Dentistry, Endodontics and Dental Materials, Bauru Dental School University of São Paulo Bauru Brazil.
Pablo Andres Amoroso-SilvaDepartment of Restorative Dentistry Universidade Estadual de Londrina Londrina Paraná Brazil.
Marco Antônio Húngaro DuarteDepartment of Dentistry, Endodontics and Dental Materials, Bauru Dental School University of São Paulo Bauru Brazil.
Guilherme Ferreira da SilvaDepartment of Dentistry, Endodontics and Dental Materials, Bauru Dental School University of São Paulo Bauru Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report describes the successful treatment of a mature anterior tooth with an open apex and chronic apical abscess using a regenerative endodontic procedure. A 36-year-old man with a history of trauma to tooth 11 at age 10 presented with incomplete root development and an asymptomatic chronic apical abscess. Cone beam tomography revealed a periradicular lesion with buccal bone plate loss. After biomechanical preparation using K-type files and irrigation with 1% sodium hypochlorite, calcium hydroxide was placed as intracanal medication for 14 days. Bleeding was induced by overinstrumenting the periapical tissues with a #25 K-file, and a bioceramic material was placed over the blood clot, followed by a composite resin coronal seal. At the 4-year follow-up, the patient was asymptomatic, with complete bone plate formation and no periradicular lesion or root resorption, although no hard tissue formation or changes in root canal morphology were observed.

Indexed as

endodonticspulp necrosisregenerativerevascularization

Identifiers

PMID40995393
PMCPMC12453967

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.