Evidence map›Paper›PMID 40995382›Full record

ArticleEncyclopedia2025

The Hippo Pathway in Kidney Development.

Caroline M Lara, Toni Castro Torres, Usaid Mazhar, Dorrian G Cohen, Rebecca A Wingert

Abstract read
In one paragraph

Article in Encyclopedia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Caroline M LaraDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Toni Castro TorresDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0003-0498-5452
Usaid MazharDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Dorrian G CohenDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0009-0005-0546-5127
Rebecca A WingertDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0003-3133-7549

Funding

Generation of novel models of kidney defects using the zebrafishR01DK100237 · NIDDK · UNIVERSITY OF NOTRE DAME · PI WINGERT, REBECCA ANN · 2013 to 2017
$1.8M
NIDDK NIH HHS R01 DK100237
6 · The paper itself

Abstract

The kidney, a complex organ crucial for a multitude of homeostatic functions, including the maintenance of fluid and electrolyte balance, removal of various metabolic waste products, and hormone production, undergoes intricate developmental processes to form functional nephron units. Understanding the mechanisms behind kidney development is paramount for elucidating the etiology of renal congenital disabilities and acquired diseases. The Hippo pathway is known for its involvement in various cellular functions, including cell fate determination and differentiation, and is a critical player in renal organogenesis. Here, we discuss research findings about the roles that Hippo signaling plays in kidney formation.

Indexed as

Hippo pathwaykidney developmentnephronTAZYAP

Identifiers

PMID40995382
PMCPMC12456234

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.