Evidence map›Paper›PMID 40995351›Full record

ArticleCHEST pulmonary2025

Racialized economic segregation and disparities in non-small cell lung cancer care and outcomes.

Pratibha Shrestha, Min Lian, James Struthers, Oumarou Nabi, Bayu B Bekele, Benjamin Kozower, Maria Baggstrom, Ying Liu

Abstract read
In one paragraph

Article in CHEST pulmonary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pratibha ShresthaDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Min LianDivision of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
James StruthersDivision of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Oumarou NabiDivision of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Bayu B BekeleDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Benjamin KozowerAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Maria BaggstromAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Ying LiuDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.

Funding

Healthcare Access Dimensions and Racial Disparities in Lung CancerR01MD015720 · NIMHD · WASHINGTON UNIVERSITY · PI LIAN, MIN, LIU, YING · 2021 to 2024
$1.6M
Impacts of Neighborhood Contexts and Medicaid Policy on Lung Cancer Survival in Low-SES PatientsR01CA268007 · NCI · WASHINGTON UNIVERSITY · PI Min Lian, Ying Liu · 2022 to 2026
$1.4M
NCI NIH HHS R01 CA268007NIMHD NIH HHS R01 MD015720
6 · The paper itself

Abstract

backgroundLittle is known about the impact of residential segregation on early detection, treatment, and prognosis of non-small cell lung cancer (NSCLC), a predominant type of lung cancers. RESEARCH QUESTION: Does racialized economic segregation play a role in NSCLC treatment and outcomes and contribute to racial disparities? STUDY DESIGN AND

methodsThis study included non-Hispanic White (NHW) and non-Hispanic Black (NHB) patients with NSCLC diagnosed between 2007 and 2015 and identified from the Surveillance, Epidemiology, and End Results dataset. County-level racialized economic segregation was estimated using the Index of Concentration at the Extremes (ICE). Multilevel logistic regression and multilevel Cox regression accounting for county-level clustering were used to estimate odds ratios (ORs) for late-stage diagnosis and treatment underutilization, and hazard ratio (HR) for mortality.

resultsOf 203,441 patients, 85.8% were NHW and 14.2% were NHB. Compared with patients living in the counties with the highest concentration of high-income NHW households (lowest ICE quintile), patients living in the counties with the highest concentration of low-income NHB households (highest ICE quintile) had higher risks of late-stage diagnosis (OR=1.09, 95% CI: 1.02-1.16;

interpretationLiving in segregated, low-income NHB counties had adverse impacts on early detection, treatment, and outcomes of NSCLC. However, residential segregation did not explain the excess risks of NSCLC care underutilization and mortality in NHB patients compared with NHW patients.

Indexed as

lung cancerracial disparityresidential segregation

Identifiers

PMID40995351
PMCPMC12456404

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.