ArticleTaiwan journal of ophthalmology
Endophthalmitis after intravitreal injection with or without triamcinolone - A 10-year investigation in a tertiary hospital.
Article in Taiwan journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeIntravitreal injections (IVIs) have been the most important treatment strategies in retinal diseases. With the increasing use of IVIs, the incidence of endophthalmitis has inevitably risen. Triamcinolone acetonide (TA) used in IVIs has been suspected as a risk factor for post-IVI endophthalmitis. This study investigates the incidence, clinical presentations, and microscopic findings of post-IVI endophthalmitis with or without TA, aiming to provide a better understanding of this issue. MATERIALS AND
methodsThis retrospective study included patients receiving IVIs at a tertiary referral center from September 2010 to August 2020. Injections were performed under sterile conditions, and endophthalmitis was diagnosed based on acute ocular symptoms within 6 weeks postinjection. Statistical analysis was preformed between endophthalmitis with or without TA.
resultsOut of 18,365 IVIs, the incidence of endophthalmitis was 0.038%. The incidence of TA-associated endophthalmitis (TAAE) (5 in 939 IVIs, 0.532%) was significantly higher (
conclusionThis study highlights that TA is significantly associated with a higher incidence of post-IVI endophthalmitis, which is also significantly associated with culture-negative results. This implies the possibility of a noninfectious cause in TAAE.
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