ArticleTaiwan journal of ophthalmology
Alterations in the foveal avascular zone and surrounding capillary network as important indicators of visual prognosis for hereditary macular dystrophy.
Article in Taiwan journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeHereditary macular dystrophy (MD) usually severely affects the central vision. This study aimed to explore macular microcirculation and its relationship with disease progression in different morphological patterns of MD. MATERIALS AND
methodsSixty-five patients with MD and 26 healthy participants were included. Panel-based next-generation sequencing (NGS), fundus autofluorescence (FAF), and optical coherence tomography angiography (OCTA) were used for genetic diagnosis, morphological classification, and evaluation of macular microcirculation, respectively. Patients were divided into two groups: the central lesion group (CLG) and the dispersed lesion group (DLG), based on FAF findings. The alterations in microcirculation between the groups and subgroups were analyzed and correlated with visual preservation.
resultsA high diagnostic rate of disease-causing genes was achieved with a panel-based NGS test (72.3%). Compromised macular microcirculation was seen in MD of all genotypes. Enlargement of the foveal avascular zone and decreased foveal vessel density was significantly correlated with impaired vision (both
conclusionOCTA is a reliable, noninvasive tool for evaluating the microcirculation of MD. Our results demonstrate that compromised macular microcirculation occurs with MD, and foveal microcirculation is crucial for visual preservation.
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