Evidence map›Paper›PMID 40995321›Full record

ReviewTaiwan journal of ophthalmology

Shining light on photoreceptors: A minireview on the development and clinical applications of optoretinography.

Alexander Matteson, Anna Andrews, David Huang, Siyu Chen

Abstract readReview
In one paragraph

Review in Taiwan journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander MattesonDepartment of Biomedical Engineering, Casey Eye Institute, Oregon Health and Science University School of Medicine, Portland, OR, USA.
Anna AndrewsDepartment of Biomedical Engineering, Casey Eye Institute, Oregon Health and Science University School of Medicine, Portland, OR, USA.
David HuangDepartment of Ophthalmology and Department of Biomedical Engineering, Casey Eye Institute, Oregon Health and Science University School of Medicine, Portland, OR, USA.
Siyu ChenDepartment of Ophthalmology and Department of Biomedical Engineering, Casey Eye Institute, Oregon Health and Science University School of Medicine, Portland, OR, USA.

Funding

Optical Assessment of Photoreceptor Function and IntegrityR01EY036413 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Siyu Chen · 2025 to 2026
$1.1M
NEI NIH HHS R01 EY036413
6 · The paper itself

Abstract

Retinal diseases often result in photoreceptor dysfunction and cell death, leading to progressive vision impairment and eventual blindness. Clinical management can benefit from assessing photoreceptor mediated visual function, such as for progression monitoring. Meanwhile, therapeutic development requires accurate and reliable vision end points. The emerging optoretinography (ORG) technologies promise noninvasive, objective, and highly sensitive markers of photoreceptor function. ORG is an umbrella term that covers several imaging modalities that use intrinsic optical signal, i.e., without dyes or labeling agents, to quantify photoreceptor responses to light. Early studies showed stimulus-evoked light scattering and morphological changes in isolated photoreceptor and retina, which provided the experimental foundation for subsequent inquires

Indexed as

Functional imagingoptoretinographyphotoreceptorsretinal degeneration

Identifiers

PMID40995321
PMCPMC12456911

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.