ArticleTaiwan journal of ophthalmology
Quantitative optical coherence tomography angiography biomarkers of the choriocapillaris for objective detection of early diabetic retinopathy.
Article in Taiwan journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Analysis of macular and optic nerve vasculature using optical coherence tomography angiography in patients with human T-cell lymphotropic virus type 1.Frontiers in neurology · 2026Article
- Exploring the Relationship Between Health Biomarkers and Performance on a Novel Color Perimetry Device in Prediabetes and Type 2 Diabetes.Diabetology · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
purposeTo evaluate quantitative optical coherence tomography (OCT) angiography (OCTA) biomarkers from the choriocapillaris (CC) for detecting early microvascular changes associated with diabetic retinopathy (DR). MATERIALS AND
methodsIn this retrospective study, 191 macular OCTA images were analyzed from 78 healthy eyes, 64 eyes from diabetic individuals without clinical signs of DR (NoDR), and 49 eyes with mild nonproliferative DR (NPDR). Five CC biomarkers were extracted from 6 mm × 6 mm enface OCTA images: flow deficit density (FDD), FD number (FDN), mean FD size (MFDS), perfusion intensity density (PID), and normalized blood flow index (NBFI). Flow maps were binarized using Phansalkar local thresholding, and statistical comparisons were performed using one-way analysis of variance and two-sample t-tests.
resultsAll five biomarkers demonstrated significant differences across study groups (
conclusionQuantitative OCTA biomarkers of the CC reveal early microvascular changes in diabetic eyes. Among them, FDN and MFDS demonstrated the highest sensitivity to early disease progression. These findings support the use of CC-derived OCTA features as potential imaging biomarkers for detecting and monitoring early diabetic microvascular dysfunction.
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