ReviewCureus2025
Topical Isotretinoin: Current Applications, Challenges, and Future Directions.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Nanoformulations in Acne Therapy: Translational Opportunities and Barriers for Next-Generation Topical Treatments.AAPS PharmSciTech · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Topical isotretinoin is designed to work locally on the skin with limited systemic absorption and is being explored as a potential alternative to more commonly used topical retinoids. However, limited research, formulation challenges, and regulatory hurdles have slowed its path to widespread use. It appears to perform similarly to other topical retinoids and may offer added benefits such as improved tolerability and greater formulation stability. Additionally, its ability to integrate into combination therapies may further enhance its clinical utility. Despite these benefits, the lack of extensive randomized controlled trials limits understanding of its optimal use, long-term effects, and safety profile. Future research is essential to determine its role in dermatologic treatment, but its potential to expand therapeutic options remains promising.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.