ArticleCureus2025
Latent Autoimmune Diabetes in Adults: A Case Series and Clinical Insights.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Proteomic Changes in Patients with LADA-Type Diabetes: Prospects for Diagnostic Biomarkers.International journal of molecular sciences · 2026Review
- Latent autoimmune diabetes in Saudi adults aged 30-55 years old seen at a tertiary hospital in Riyadh, Saudi Arabia.Journal of family medicine and primary care · 2026Article
- Risk of Hypoglycemia and Associated Factors Among In-Hospital Chinese Patients With Latent Autoimmune Diabetes in Adults (LADA): A Multicenter Retrospective Cohort Study.Journal of diabetes research · 2026Article
- Autoimmune Phenotype Confirmation Intervals and Clinical Indicators in Patients With Latent Autoimmune Diabetes in Adults (LADA) in Southwest China: A Multicenter Retrospective Cross-Sectional Study.Journal of diabetes research · 2026Observational
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDiabetes mellitus (DM) is a disease spectrum ranging from classic insulin deficiency of type 1 diabetes (T1DM) to insulin-resistant type 2 diabetes (T2DM). Latent autoimmune diabetes in adults (LADA) is a type of DM with clinical characteristics of both T1DM and T2DM. Despite its clinical significance, LADA remains underdiagnosed and mismanaged due to overlapping characteristics with other diabetes types. Methods: It is a case series describing clinical, immunological, and metabolic characteristics of ten patients diagnosed with LADA based on three criteria identified by the Immunology of Diabetes Society.
resultsWe found that these patients had uncontrolled diabetes not controlled with oral hypoglycemic drugs, were mostly males aged above 30 years with a mean body mass index of 22.6 kg/m², and everyone had positive anti-glutamic acid decarboxylase (GAD) antibody. At the presentation, one patient had combined moderate non-proliferative diabetic retinopathy and peripheral neuropathy. Four patients had mild non-proliferative diabetic retinopathy, and two had peripheral neuropathy as complications of uncontrolled diabetes.
conclusionLADA remains a diagnostic challenge, as its phenotypic picture resembles T2DM, while immunologically it resembles T1DM. A high index of suspicion, early diagnosis, and correct treatment can prevent further damage to the beta islet cells and help prevent short-term and long-term complications of DM.
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