Use of Diperoxochloric Acid as a Novel Therapy for the Treatment of Infected Traumatic Foot Ulcers: A Case Series.

Infected traumatic foot ulcers present a significant therapeutic challenge, particularly in patients with delayed presentation, suboptimal hygiene, or comorbidities like diabetes and peripheral vascular disease. Conventional management includes wound debridement, systemic antibiotics, and advanced dressings, often with variable success. Diperoxochloric acid (DPA), a potent oxidizing agent with broad-spectrum antimicrobial properties, has recently gained attention for its potential in promoting wound healing while simultaneously reducing the microbial load. In this case series, we present four patients with moderate to severe infected foot ulcers following trauma, all of whom showed minimal improvement after at least 14 days of standard wound care and systemic antibiotic therapy. Upon introduction of topical DPA as an adjunctive treatment along with serial wound debridement, all cases demonstrated significant clinical improvement, with a rapid reduction in wound size (average decrease of 60% within three weeks), resolution of infection, and progressive granulation leading to complete healing in an average of 6.5 weeks. Compared to traditional antiseptics, DPA offers several advantages, including reduced cytotoxicity, sustained antimicrobial activity, and enhanced wound bed preparation, making it a compelling adjunct in chronic and infected wound care. This series highlights the potential of DPA as a cost-effective, efficient, and well-tolerated adjunct in the multidisciplinary management of infected traumatic foot ulcers. Future prospective studies with larger cohorts are warranted to further elucidate optimal protocols, long-term outcomes, and cost-effectiveness.