ArticleBrain, behavior, & immunity - health2025
Cumulative social advantage is associated with slower epigenetic aging and lower systemic inflammation.
Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Epigenetic Age Acceleration Is Associated With HIV Infection Independently of Inflammation.Open forum infectious diseases · 2026Article
- Epigenetic Clocks, Resilience, and Multi-Omics Ageing: A Review and the EpiAge-R Conceptual Framework.International journal of molecular sciences · 2026Review
- Gender differences in the association between marriage and epigenetic age.Frontiers in aging · 2026Article
- Is accelerated biological aging the hidden link between physical frailty, social deficits, cognitive impairment and risk of incident diseases?The journal of nutrition, health & aging · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Social relationships are established determinants of health across the lifespan, yet the cumulative and multidimensional effects of sustained social advantage on biological aging remain poorly understood. Methods: Drawing on data from 2117 adults in the Midlife in the United States (MIDUS) study, we used structural equation modeling to examine whether cumulative social advantage (CSA)-a latent construct encompassing social connection across familial, religious, emotional, and community domains-was associated with epigenetic aging, systemic inflammation, and neuroendocrine activity. Results: Higher CSA was linked to slower epigenetic aging, particularly as indexed by GrimAge (β = -0.09 to -0.10, Conclusion: Sustained social advantage is associated with more favorable biological aging profiles, including slower epigenetic aging and reduced inflammatory signaling. These findings add to growing evidence that social resources are embedded in the physiological pathways that shape aging and health.
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Registered trials
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