Evidence map›Paper›PMID 40995124›Full record

ArticleiScience2025

Nicolas Diaz, Sondip Biswas, Wei Zhong, Khaleel Bashir, Ting Chung Suen, Jason DeBruyne, Paul Michael Iuvone, Gianluca Tosini, Hao Duong, Sharon Francis and 1 more

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicolas DiazDepartment of Pharmacology and Toxicology & Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Sondip BiswasDepartment of Pharmacology and Toxicology & Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Wei ZhongDepartment of Physiology & Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Khaleel BashirDepartment of Pharmacology and Toxicology & Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Ting Chung SuenDepartment of Pharmacology and Toxicology & Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Jason DeBruyneDepartment of Pharmacology and Toxicology & Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Paul Michael IuvoneDepartments of Ophthalmology and Pharmacology & Chemical Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Gianluca TosiniDepartment of Pharmacology and Toxicology & Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Hao DuongDepartment of Pharmacology and Toxicology & Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Sharon FrancisDepartment of Physiology & Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Kenkichi BabaDepartment of Pharmacology and Toxicology & Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.

Funding

The retinal clock modulates cell viability, retinal circuitry and locomotor activity rhythmSC1GM135112 · NIGMS · MOREHOUSE SCHOOL OF MEDICINE · PI BABA, KENKICHI · 2021 to 2024
$1.4M
NIGMS NIH HHS SC1 GM135112
6 · The paper itself

Abstract

The mammalian retina contains an autonomous circadian system that regulates ocular physiology. The deletion of the core clock gene Bmal1 in the mouse retina disrupts retinal circuitry, alters cone spectral identity, and reduces cone viability. Cone photoreceptors have the highest energy demand among retinal neurons and are continuously exposed to high levels of oxidative stress, making them susceptible to mitochondrial dysfunction. To investigate the role of

Indexed as

biochemistrycell biologyspecialized functions of cells

Identifiers

PMID40995124
PMCPMC12455009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.