Evidence map›Paper›PMID 40995117›Full record

ArticleiScience2025

Immune microenvironment and fibroblast subpopulation in diabetic wound healing.

Jing Gan, Yuanrong Chen, Lu Tang, Hui Dong, Xiaotang Gao, Yunfeng Huang, Yang Pan, Jing Hong, Zhibiao Bai, Xiong Chen and 2 more

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Transcriptomic Profiling of Diabetic Porcine Wound Healing Model Identifies Key Metabolic, Inflammatory, and Oxidative Stress Pathways.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jing GanDepartment of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Yuanrong ChenDepartment of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Lu TangSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Hui DongDepartment of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Xiaotang GaoSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Yunfeng HuangDepartment of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Yang PanDepartment of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Jing HongDepartment of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Zhibiao BaiDepartment of Orthopaedics, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Xiong ChenDepartment of Orthopaedics, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Zhuofeng LinThe Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan 523326, China.
Hong ZhuDepartment of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic foot ulcer (DFU) presents a major clinical challenge due to impaired healing mechanisms. Through the single-cell RNA sequencing of granulation tissue during wound repair, we identified distinct cellular alterations in DFU. Our analysis revealed an inflammatory monocyte axis involving

Indexed as

ImmunologyMicroenvironmentTranscriptomics

Identifiers

PMID40995117
PMCPMC12454276

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.