Evidence map›Paper›PMID 40995071›Full record

ArticleACS applied nano materials2024

Ionic-Liquid-Modified Nanoparticles as Potential Mucus Modulators for Nasal Drug Delivery.

Mary E VanLandingham, Rebekah A Heintz, Chathuri S Kariyawasam, Donovan S Darlington, Claylee M Chism, Sara X Edgecomb, Angela Roberts, Jorden Marzette, Nicholas C Fitzkee, Eden E L Tanner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied nano materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mary E VanLandinghamDepartment of Chemistry and Biochemistry, The University of Mississippi, Oxford, Mississippi 38677, United States.ORCID 0000-0002-9976-3555
Rebekah A HeintzDepartment of Chemistry and Biochemistry, The University of Mississippi, Oxford, Mississippi 38677, United States.
Chathuri S KariyawasamDepartment of Chemistry, Mississippi State University, Starkville, Mississippi 39762, United States.
Donovan S DarlingtonDepartment of Chemistry and Biochemistry, The University of Mississippi, Oxford, Mississippi 38677, United States.
Claylee M ChismDepartment of Chemistry and Biochemistry, The University of Mississippi, Oxford, Mississippi 38677, United States.
Sara X EdgecombDepartment of Chemistry and Biochemistry, The University of Mississippi, Oxford, Mississippi 38677, United States.
Angela RobertsDepartment of Chemistry and Biochemistry, The University of Mississippi, Oxford, Mississippi 38677, United States.
Jorden MarzetteDepartment of Chemistry and Biochemistry, The University of Mississippi, Oxford, Mississippi 38677, United States.
Nicholas C FitzkeeDepartment of Chemistry, Mississippi State University, Starkville, Mississippi 39762, United States.ORCID 0000-0002-8993-2140
Eden E L TannerDepartment of Chemistry and Biochemistry, The University of Mississippi, Oxford, Mississippi 38677, United States.

Funding

Structure, Orientation, and Competitive Interactions of S. Epidermidis Biofilm Proteins on SurfacesR01AI139479 · NIAID · MISSISSIPPI STATE UNIVERSITY · PI FITZKEE, NICHOLAS C · 2018 to 2022
$1.8M
The Structure, Orientation, and Competitive Interactions of S. Epidermidis Biofilm Proteins on SurfacesR56AI139479 · NIAID · MISSISSIPPI STATE UNIVERSITY · PI FITZKEE, NICHOLAS C · 2024 to 2024
$417k
NIAID NIH HHS R01 AI139479NIAID NIH HHS R56 AI139479
6 · The paper itself

Abstract

Mucosal barriers are a natural defense system for preventing the entry of foreign objects into the body; however, they pose obstacles for effective drug delivery. Coated polymer nanoparticles (NPs) have been shown to possess improved rates of diffusion across mucus compared to their uncoated, or bare, counterparts. Choline carboxylic acid-based ionic liquids (ILs) are highly tunable and show high biocompatibility and mucus modulation properties, making them an ideal choice for the improvement of NP diffusion through mucosal barriers. This study aimed to investigate whether the use of choline-based ILs has a positive effect on the dispersibility of poly(lactic-

Indexed as

diffusiondrug deliveryionic liquidsmucinmucusnanoparticles

Identifiers

PMID40995071
PMCPMC12456362

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.