Evidence map›Paper›PMID 40995048›Full record

ArticleOpen forum infectious diseases2025

Preoperative Enterosignatures Predict Surgical Site Infections After Abdominal Surgery.

Simone N Zwicky, Daniel Spari, Daniel Rodjakovic, Hugo Guillen-Ramirez, Bahtiyar Yilmaz, Guido Beldi

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Simone N ZwickyDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0003-4465-6813
Daniel SpariDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Daniel RodjakovicDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Hugo Guillen-RamirezDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Bahtiyar YilmazDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Guido BeldiDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-9914-3807

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The relationship between preoperative intestinal microbiota composition and the development of surgical site infections (SSIs) following abdominal surgery is not well understood. The aim of this study was to characterize the preoperative rectal microbiota using the novel concept of enterosignatures (ESs) in patients undergoing abdominal surgery and assess their association with SSIs. Methods: In this prospective cohort study, preoperative rectal microbiota from 133 patients undergoing elective abdominal surgery was profiled using 16S rRNA sequencing. ESs were calculated using high-quality genus-level taxonomy, simplifying complex microbial compositions into 5 generalizable patterns: Results: A total of 519 bacterial species were identified within the 133 patients. The Conclusions: The ES-Firm-Prev ratio is a robust, independent predictor of SSIs in patients undergoing abdominal surgery and may serve as a novel biomarker to identify high-risk patients preoperatively.

Indexed as

enterosignaturesmicrobiota profilingsurgical site infection

Identifiers

PMID40995048
PMCPMC12456171

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.