ArticlePolymer science & technology (Washington, D.C.)2025
Influence of Side-Chain Molecular Features on Aqueous Coacervation of Multifunctional Homopolypeptides.
Article in Polymer science & technology (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Complex coacervate tissue adhesives: effect of polycation chemistry and ionic strength on cytocompatibility.Journal of materials science. Materials in medicine · 2026Article
- NIR-II Light-Modulated Smart Drug Delivery System Utilizing Drug-Gated Nanocomposite Hydrogel for Boosting Anticancer Efficacy.Polymer science & technology (Washington, D.C.) · 2025Article
- Synthetic Polymers for Drug, Gene, and Vaccine Delivery.Polymer science & technology (Washington, D.C.) · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three different series of amino acid side-chain functionalized homopolypeptides were prepared as variants of previously reported α-helical, coacervate-forming cationic polypeptides. Studies of the physical behavior of these polypeptides in aqueous media in the presence of multivalent counterions enabled a better understanding of the molecular requirements for coacervate formation of side-chain functionalized homopolypeptides. Variation in lengths of side-chain amino acid or linker segments in cationic α-helical polypeptides was found either to prohibit coacervate formation or to allow adjustment of the phase transition temperature. A series of charge-reversed, anionic amino acid side-chain functionalized homopolypeptides were also prepared and found to be α-helical and able to form coacervates similar to analogous cationic homopolypeptides. These results illustrate the ability to predictably tune coacervation properties via molecular adjustment of side-chains in homopolypeptides and show that amino acid side-chain functionalized homopolypeptides can be used as a general platform for development of biomimetic, coacervate-forming polymers.
Identifiers
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Registered trials
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