ArticleFrontiers in microbiology2025
Comprehensive discovery and functional characterization of diverse prophages in the pig gut microbiome.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Gut virome-microbiome interactions across hosts and environments.NPJ biofilms and microbiomes · 2026Article
- Characterization of the gut phageome and functional genes carried by phages in laying hens with fatty liver hemorrhagic syndrome.Microbiome · 2026Article
- Large-scale genomic analysis of jumbo phages: coevolution, genome architecture, and host interaction mechanisms.Animal microbiome · 2026Article
- Comprehensive analysis of phage genomes from diverse environments reveals their diversity, potential applications, and interactions with hosts and other phages.Frontiers in microbiology · 2025Article
- Comprehensive genome analysis uncovers the diversity of jumbo phages in the pig gut microbiome.Frontiers in veterinary science · 2025Article
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Authors and funding
3 authors.
Funding
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Abstract
Prophages, viruses integrated into bacterial or archaeal genomes, can carry cargo that confers beneficial phenotypes to the host. The porcine gut microbiota constitutes a complex, dynamic, and interconnected ecosystem, yet the distribution of prophages and their unique functional characteristics within this microbial community remains poorly understood. In this study, we identified 10,742 prophage genomes through systematic screening of 7,524 prokaryotic genomes from porcine gut sources, representing both bacterial and archaeal lineages, with the distribution of integrated prophages exhibiting pronounced heterogeneity across host species. Additionally, 1.70% (183/10,742) of prophages exhibited a broad host range infectivity, while 5.07% (545/10,742) of integrated prophages enhanced prokaryotic adaptive immune capabilities by augmenting or directly providing host defense mechanisms. Notably, within tripartite phage-phage-host interactions network analysis, we observed that these prophages (
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