Evidence map›Paper›PMID 40994821›Full record

ArticleBrain communications2025

Impact of age on neurofilament light chain in Friedreich ataxia: a 1-year longitudinal study.

Sara Petrillo, Alessia Mongelli, Anna Castaldo, Lidia Sarro, Samuele Azzarelli, Riccardo Ronco, Barbara Castellotti, Cinzia Gellera, Fiorella Piemonte, Caterina Mariotti

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara PetrilloUnit of Muscular and Neurodegenerative Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome 00165, Italy.
Alessia MongelliNeurology Department, NRSC, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milano 20133, Italy.
Anna CastaldoNeurology Department, NRSC, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milano 20133, Italy.
Lidia SarroNeurology Department, NRSC, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milano 20133, Italy.
Samuele AzzarelliNeurology Department, NRSC, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milano 20133, Italy.
Riccardo RoncoNeurology Department, NRSC, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milano 20133, Italy.
Barbara CastellottiUnit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano 20133, Italy.
Cinzia GelleraUnit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano 20133, Italy.
Fiorella PiemonteUnit of Muscular and Neurodegenerative Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome 00165, Italy.
Caterina MariottiNeurology Department, NRSC, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milano 20133, Italy.ORCID https://orcid.org/0000-0003-2405-3564

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Friedreich's ataxia (FRDA) is a recessive inherited ataxia caused by intronic GAA repeat expansions in

Indexed as

Friedreich ataxialongitudinal studyneurofilament light chainpediatric population

Identifiers

PMID40994821
PMCPMC12455201

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.