ArticleMatter2025
Matrix stiffness regulates traction forces, cytoskeletal dynamics, and collagen reorganization in trabecular meshwork cells in glaucoma.
Article in Matter, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Segmental flow responses in glaucomatous trabecular meshwork cells.Biomaterials advances · 2026Article
- Differential Cytoskeletal Control of Cell-Collagen Mechanics in High- and Low-Flow Glaucomatous Trabecular Meshwork Cells.ACS applied materials & interfaces · 2026Article
- Composition Matters: Collagen vs Polyacrylamide Modulates Distinct Trabecular Meshwork Cell Traction.ACS biomaterials science & engineering · 2026Article
- Segmental Mechanobiology of Normal and Glaucomatous Human Trabecular Meshwork Cells.ACS measurement science au · 2026Article
- Flow-dependent traction in high- and low-flow normal trabecular meshwork cells.Acta biomaterialia · 2026Article
- Bioengineered 3D Human Trabecular Meshwork Models for Outflow Physiology and Glaucoma Research.Bioengineering (Basel, Switzerland) · 2026Review
- 3D traction force microscopy in human trabecular meshwork tissues: Effects of ROCK and YAP/TAZ inhibition in normal and glaucomatous tissues.Tissue & cell · 2025Article
- Actin-microtubule synergy dominates force transmission and collagen strain in human trabecular meshwork.Acta biomaterialia · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Increased adhesion forces between trabecular meshwork (TM) cells and the extracellular matrix (ECM) in the human outflow pathway are associated with elevated intraocular pressure (IOP), a key risk factor for primary open-angle glaucoma (POAG). This study examined how matrix stiffness affects traction forces and collagen fibril organization in normal and glaucomatous TM cells using collagen gels with stiffness levels of 4.7 and 27.7 kPa. Normal high-flow (HF) TM/JCT cells showed greater traction forces on the stiffer gels, whereas glaucomatous HF TM/JCT cells generated greater forces on the softer gels. These differences correlated with findings that normal cells are ~1.6-fold stiffer than their glaucomatous counterparts. Glaucomatous cells also exhibited anisotropic collagen fibril alignment and distinct cytoskeletal dynamics. These results suggest that altered mechanosensitivity and ECM reorganization in glaucomatous TM cells may contribute to promoting ECM stiffening, elevated IOP, and disease progression, highlighting potential therapeutic strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.