Evidence map›Paper›PMID 40994733›Full record

ArticlePain reports2025

Eyelid heat pain sensitivity in healthy participants.

Nicholas J Pondelis, Vanda Faria, Hailey Krasnikov, Cameron Talbert, Madison Dudek, Paula A Sepulveda-Beltran, David Valdes-Arias, David Zurakowski, Anat Galor, Scott Holmes and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nicholas J PondelisBrain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0003-4666-5801
Vanda FariaBrain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Hailey KrasnikovBrain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Cameron TalbertBrain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Madison DudekBrain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Paula A Sepulveda-BeltranBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
David Valdes-AriasBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
David ZurakowskiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Anat GalorBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Scott HolmesPediatric Pain Pathways Lab, Pain and Affective Neuroscience Center, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Elizabeth R FelixDepartment of Physical Medicine and Rehabilitation, University of Miami Miller School of Medicine, Miami, FL, USA.
Eric A MoultonBrain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Funding

Differentiation of Clinical Phenotypes of Inflammatory and Neuropathic Ocular Pain Conditions with Morphologic Measures and Functional Brain ImagingU01EY034686 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Eric Alan Moulton · 2022 to 2026
$4.7M
The trigeminal nociceptive-pain pathway in pediatric mTBI: peripheral and central contributions to photophobiaR01EY034135 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Scott Holmes, Eric Alan Moulton · 2023 to 2026
$1.9M
NEI NIH HHS R01 EY034135NEI NIH HHS U01 EY034686
6 · The paper itself

Abstract

Introduction: Chronic ocular pain (COP) is a widespread pain condition that presents clinical challenges, has heterologous and overlapping etiologies across patients, and can have a debilitating effect on quality of life. It can manifest with neuropathic-like symptoms as well as dysesthesias associated with afferent disruption, brain dysfunction, or both, complicating diagnosis and treatment. Quantitative sensory testing (QST) has been used extensively in individuals with chronic pain to detect abnormal peripheral and central nervous system function. Investigating relevant sensory thresholds is crucial for integrating QST into ocular pain assessments. Objectives: This study aimed to determine heat pain thresholds on the eyelid in healthy participants. Furthermore, we sought to evaluate the eyelid as a feasible and suitable body site for COP investigation using QST. Methods: Heat pain thresholds were measured in 80 healthy participants at 2 study sites using the method of limits at 3 stimulation sites: the upper eyelid, the forehead, and the volar forearm. Results: Analysis revealed a significantly lower estimated marginal mean (EMM) heat pain threshold on the eyelid (42.5 ± 0.4 EMM ± SE) compared with the forehead (46.6 ± 0.4 EMM ± SE) ( Conclusion: The eyelid is a clinically relevant site for QST in the investigation of ocular and trigeminal function, and this study sets the groundwork for applying eyelid QST in future research of ocular pain and disease etiology.

Indexed as

NociceptionOcularOphthalmologyPsychophysiologyQSTThreshold

Identifiers

PMID40994733
PMCPMC12456492

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.