Evidence map›Paper›PMID 40994720›Full record

ArticleJournal of extracellular biology2025

Sex-Specific Differences in the Secretome of Oligodendrocyte Progenitor Cells Post Hyperoxic Stress.

Donna Elizabeth Sunny, Elke Hammer, Stephan Michalik, Uwe Völker, Matthias Heckmann

Abstract read
In one paragraph

Article in Journal of extracellular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Donna Elizabeth SunnyDepartment of Neonatology and Pediatric Intensive Care University of Medicine Greifswald Greifswald Germany.ORCID https://orcid.org/0000-0001-5595-5363
Elke HammerDepartment of Functional Genomics University of Medicine Greifswald Greifswald Germany.
Stephan MichalikDepartment of Functional Genomics University of Medicine Greifswald Greifswald Germany.
Uwe VölkerDepartment of Functional Genomics University of Medicine Greifswald Greifswald Germany.
Matthias HeckmannDepartment of Neonatology and Pediatric Intensive Care University of Medicine Greifswald Greifswald Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral oxygenation differences in the neonatal period of human preterm infants, along with sex-specific differences in combating oxidative stress, can lead to disruption of normal oligodendrocyte maturation and function, which in turn can differentially affect neuronal development and activity in the male and female brains. Secretory proteins and extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication and stress response in the brain. Our analysis of the secretome from cell culture supernatants obtained after treating male and female derived primary mouse OPCs with hyperoxia (80% O

Indexed as

hyperoxiamurine oligodendrocyte progenitor cellssectretomesex‐differences

Identifiers

PMID40994720
PMCPMC12455015

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.