Evidence map›Paper›PMID 40994704›Full record

ArticleClinical kidney journal2025

A novel CT-based radiomics approach for kidney function evaluation in ADPKD: a pilot study.

Luca Calvaruso, Pierluigi Fulignati, Luigi Larosa, Huong Elena Tran, Claudio Votta, Carla Cipri, Luigi Natale, Viola D'Ambrosio, Giulia Condello, Pietro Manuel Ferraro and 3 more

Abstract read
In one paragraph

Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Luca CalvarusoNephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-8465-8904
Pierluigi FulignatiNephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Luigi LarosaDepartment of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Huong Elena TranDepartment of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Claudio VottaDepartment of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Carla CipriDepartment of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Luigi NataleDepartment of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Viola D'AmbrosioNephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Giulia CondelloNephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Pietro Manuel FerraroSection of Nephrology, Department of Medicine, Università degli Studi di Verona, Verona, Italy.
Francesco PesceDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID https://orcid.org/0000-0002-2882-4226
Luca BoldriniDepartment of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Giuseppe GrandalianoNephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Management of autosomal dominant polycystic kidney disease (ADPKD) might take advantage of the use of new tools to predict risk of progression towards end-stage kidney disease (ESKD). The aim of this study is to explore the potential of radiomic features obtained from computed tomography (CT) scans for the prediction of kidney function decline over time of ADPKD patients. Methods: We retrospectively selected a cohort of 58 ADPKD patients who routinely underwent CT scan for total kidney volume (TKV) assessment from February 2020 to March 2021. An expert radiologist generated a region-of-interest segmentation for cystic kidneys from which we extracted 217 radiomic features. In a subgroup of 51 patients with at least three serum creatinine measurements, on the basis of estimated glomerular filtration rate we identified 26 rapid progressors to ESKD (>3 mL/min/1.73 m Results: The most statistically significant radiomic feature ( Conclusions: We developed a model based on the radiomic feature

Indexed as

autosomal dominant polycystic kidney diseaseimagingradiomicsrenal function

Identifiers

PMID40994704
PMCPMC12455199

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.