ArticleFrontiers in bioengineering and biotechnology2025
Multifunctional PEEK implants via mussel adhesion-mediated assembly for osteoimmune regulation and antibacterial properties.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Biomaterial-Driven Modulation of Macrophage Polarization in an Experimental Environment of Implant-Associated Infection Mediated byJournal of functional biomaterials · 2026Review
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Authors and funding
12 authors.
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Abstract
Introduction: Polyetheretherketone (PEEK) is widely recognized for its exceptional mechanical properties and biocompatibility, making it a promising material for orthopedic implants. However, its inherent biological inertia-characterized by poor osteogenic potential, limited antibacterial activity, and excessive immune activation-compromises its clinical performance. Methods: To address these limitations, we developed a multifunctional PEEK implant (PEEK-PDA-Sr/AMP) through a mussel-inspired self-assembly process, incorporating strontium ions (Sr Results: The resulting PEEK-PDA-Sr/AMP implants significantly promoted the adhesion and spatial organization of bone marrow mesenchymal stem cells (BMSCs) and macrophages (BMMs) in vitro. Furthermore, the modified surface facilitated macrophage polarization toward a pro-regenerative phenotype, thereby fostering an osteoimmune microenvironment conducive to osteogenic differentiation of BMSCs. The functionalized implants also exhibited strong antibacterial efficacy against both Discussion: This study demonstrates a novel surface bioengineering strategy for constructing multifunctional PEEK implants with improved immunomodulatory, osteogenic, and antibacterial properties, offering a promising solution to meet complex clinical requirements in orthopedic applications.
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