Evidence map›Paper›PMID 40994660›Full record

ArticleStructural heart : the journal of the Heart Team2025

A Novel Management to Severe Hypoattenuation Leaflet Thickening Following Transcatheter Aortic Valve Replacement.

Himax Patel, John Lester, Amr Essa, Robert Summers, Dania Al Jabri, Jarren Ypil, Kimberly Atianzar, Musa Sharkawi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Structural heart : the journal of the Heart Team, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Himax PatelDepartment of Cardiology, Wellstar Medical College of Georgia Health Medical Center, Augusta, Georgia, USA.
John LesterMedical College of Georgia, The University of Georgia, Athens, Georgia, USA.
Amr EssaDepartment of Cardiology, Wellstar Medical College of Georgia Health Medical Center, Augusta, Georgia, USA.
Robert SummersDepartment of Internal Medicine, Wellstar Medical College of Georgia Health Medical Center, Augusta, Georgia, USA.
Dania Al JabriDepartment of Internal Medicine, Wellstar Medical College of Georgia Health Medical Center, Augusta, Georgia, USA.
Jarren YpilLeeds School of Business at the University of Colorado Boulder, Boulder, Colorado, USA.
Kimberly AtianzarDepartment of Cardiology, Wellstar Medical College of Georgia Health Medical Center, Augusta, Georgia, USA.
Musa SharkawiDepartment of Cardiology, Wellstar Medical College of Georgia Health Medical Center, Augusta, Georgia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

•First reported tissue plasminogen activator use to treat hypoattenuated leaflet thickening (HALT) post-transcatheter aortic valve replacement unresponsive to standard therapy.•Low-dose thrombolysis over 48 hours restored valve function.•Complete HALT resolution confirmed on computed tomography angiography after thrombolysis.

Indexed as

HALTTAVRThrombolysis

Identifiers

PMID40994660
PMCPMC12455079

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.